Natural history of stage I twin-to-twin transfusion syndrome.
Insufficient data exists regarding the behavior of TTTS diagnosed in its earliest stage. While some cases reverse spontaneously, others progress rapidly. Currently, there are no known maternal or fetal factors that predict resolution or progression. Progression to higher stages is associated with worse outcomes. Better defining the natural course of stage I TTTS could help identify patients who are more likely to progress to higher stages, and how rapidly that progression may occur. Those patients could be offered definitive treatment such as laser photocoagulation, while those likely to resolve could be managed conservatively. The goal of this study is to better define, through a multicenter retrospective observational study design, the behavior of Quintero stage I twin-twin transfusion syndrome (TTTS), to address unanswered questions regarding disease management, and to identify demographic, sonographic and echocardiographic predictors of disease behavior.